Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells.

Temozolomide (8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4-(3H)-one) has shown promising activity in Phase I trials against some brain (glioma) and skin (melanoma, mycosis fungoides) cancers. Temozolomide and lomustine (CCNU) showed parallel toxicity in seven human tumour cell lines and thi...

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Main Authors: Baer, J. C., Freeman, A. A., Newlands, E. S., Watson, A. J., Rafferty, J. A., Margison, G. P.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1993
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1968485/
https://ncbi.nlm.nih.gov/pubmed/8512814
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