Interleukin-6 cDNA transfected Lewis lung carcinoma cells show unaltered net tumour growth rate but cause weight loss and shortened survival in syngeneic mice.

HuIL-6 cDNA, cloned into a neomycin resistant conferring expression vector, BMGNeo, was transfected into Lewis Lung Carcinoma (LLC) cells. LLC cells (5 x 10(6) ml-1) transfected with IL-6 cDNA (LLC-IL6) secreted IL-6 into the culture supernatant at a concentration of 9.9 ng ml-1 within 48 h. When 1,...

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Hauptverfasser: Ohe, Y., Podack, E. R., Olsen, K. J., Miyahara, Y., Miura, K., Saito, H., Koishihara, Y., Ohsugi, Y., Ohira, T., Nishio, K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1993
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1968462/
https://ncbi.nlm.nih.gov/pubmed/8494727
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