Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids

α-Galactosylceramide (α-GalCer), a glycolipid that stimulates natural killer T (NKT) cells to produce both T helper (Th)1 and Th2 cytokines, has shown antitumor effects in mice but failed in clinical trials. We evaluated 16 analogs of α-GalCer for their CD1-mediated T cell receptor (TCR) activation...

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Detalhes bibliográficos
Main Authors: Chang, Ya-Jen, Huang, Jing-Rong, Tsai, Yi-Chien, Hung, Jung-Tung, Wu, Douglass, Fujio, Masakazu, Wong, Chi-Huey, Yu, Alice L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1965507/
https://ncbi.nlm.nih.gov/pubmed/17566107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703824104
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