Large-scale, saturating insertional mutagenesis of the mouse genome

We describe the construction of a large-scale, orderly assembly of mutant ES cells, generated with retroviral insertions and having mutational coverage in >90% of mouse genes. We also describe a method for isolating ES cell clones with mutations in specific genes of interest from this library. Th...

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Detalhes bibliográficos
Main Authors: Gragerov, Alexander, Horie, Kyoji, Pavlova, Maria, Madisen, Linda, Zeng, Hongkui, Gragerova, Galina, Rhode, Alex, Dolka, Io, Roth, Patricia, Ebbert, Amanda, Moe, Stephanie, Navas, Christopher, Finn, Eric, Bergmann, John, Vassilatis, Demetrios K., Pavlakis, George N., Gaitanaris, George A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1964832/
https://ncbi.nlm.nih.gov/pubmed/17720809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700608104
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