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Carbon dioxide stimulates peroxynitrite-mediated nitration of tyrosine residues and inhibits oxidation of methionine residues of glutamine synthetase: Both modifications mimic effects of adenylylation

The activity of glutamine synthetase (EC 6.3.1.2) from Escherichia coli is regulated by the cyclic adenylylation and deadenylylation of Tyr-397 in each of the enzyme’s 12 identical subunits. The nitration of Tyr-397 or of the nearby Tyr-326 by peroxynitrite can convert the unadenylylated enzyme to a...

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Библиографические подробности
Главные авторы: Berlett, Barbara S., Levine, Rodney L., Stadtman, Earl R.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 1998
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC19646/
https://ncbi.nlm.nih.gov/pubmed/9501167
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