Human DNA polymerase κ uses template–primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions

Human DNA polymerase κ (hPolκ) is a proficient extender of mispaired primer termini on undamaged DNA, wherein it extends directly by incorporating the next correct nucleotide, generating single-base substitutions in the process. Biochemical and genetic studies, however, have indicated that, in addit...

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Bibliographic Details
Main Authors: Wolfle, William T., Washington, M. Todd, Prakash, Louise, Prakash, Satya
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2003
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC196459/
https://ncbi.nlm.nih.gov/pubmed/12952891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1108603
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