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Intra-Organ Variation in Age-Related Mutation Accumulation in the Mouse
Using a transgenic mouse model harboring chromosomally integrated lacZ mutational target genes, we previously demonstrated that mutations accumulate with age much more rapidly in the small intestine than in the brain. Here it is shown that in the small intestine point mutations preferentially accumu...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1964533/ https://ncbi.nlm.nih.gov/pubmed/17849005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000876 |
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