Intra-Organ Variation in Age-Related Mutation Accumulation in the Mouse

Using a transgenic mouse model harboring chromosomally integrated lacZ mutational target genes, we previously demonstrated that mutations accumulate with age much more rapidly in the small intestine than in the brain. Here it is shown that in the small intestine point mutations preferentially accumu...

Full description

Saved in:
Bibliographic Details
Main Authors: Busuttil, Rita A., Garcia, Ana Maria, Reddick, Robert L., Dollé, Martijn E. T., Calder, Robert B., Nelson, James F., Vijg, Jan
Format: Artigo
Language:Inglês
Published: Public Library of Science 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1964533/
https://ncbi.nlm.nih.gov/pubmed/17849005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000876
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items