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Epigenetics, mismatch repair genes and colorectal cancer.
The recent discovery of hypermethylation of the promoter of genes is a powerful epigenetic mechanism for the inactivation of tumour suppressor genes in colorectal and other cancers. Approximately 95% of hereditary non-polyposis colorectal cancers (HNPCCs) and 15% of sporadic colorectal cancers (CRCs...
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| Главный автор: | |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Royal College of Surgeons of England
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1963859/ https://ncbi.nlm.nih.gov/pubmed/15720901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1308/1478708051423 |
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