cAMP promotes pancreatic β-cell survival via CREB-mediated induction of IRS2

The incretin hormone GLP1 promotes islet-cell survival via the second messenger cAMP. Here we show that mice deficient in the activity of CREB, caused by expression of a dominant-negative A-CREB transgene in pancreatic β-cells, develop diabetes secondary to β-cell apoptosis. Remarkably, A-CREB sever...

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Detalhes bibliográficos
Main Authors: Jhala, Ulupi S., Canettieri, Gianluca, Screaton, Robert A., Kulkarni, Rohit N., Krajewski, Stan, Reed, John, Walker, John, Lin, Xueying, White, Morris, Montminy, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC196130/
https://ncbi.nlm.nih.gov/pubmed/12842910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1097103
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