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Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells
To dissect apoptotic genes governing the survival of colorectal carcinoma cells, we employed RNAi to silence Bcl-2 and Bcl-x(L) in isogenic clones of p53+/+ and p53−/− cells, and of Bax+/− and Bax−/− cells. We identify a novel proapoptotic function of p53 that does not require activation by genotoxi...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC196025/ https://ncbi.nlm.nih.gov/pubmed/12670866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.252603 |
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