G1 cyclin-dependent kinases are insufficient to reverse dE2F2-mediated repression

Here we show that the cell cycle defects of dE2F1-depleted cells depend on the cooperative effects of dE2F2 and DACAPO (DAP), an inhibitor of Cyclin E/cyclin-dependent kinase 2 (CycE/cdk2). The different properties of cells lacking dE2F1/dE2F2 and dE2F1/DAP lead to the surprising observation that dE...

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Detalhes bibliográficos
Main Authors: Frolov, Maxim V., Stevaux, Olivier, Moon, Nam-Sung, Dimova, Dessislava, Kwon, Eun-Jeong, Morris, Erick J., Dyson, Nicholas J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC196013/
https://ncbi.nlm.nih.gov/pubmed/12651890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1031803
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