The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains

The repression of the maternally inherited Igf2 allele has been proposed to depend on a methylation-sensitive chromatin insulator organized by the 11 zinc finger protein CTCF at the H19 imprinting control region (ICR). Here we document that point mutations of the nucleotides in physical contact with...

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Detalhes bibliográficos
Main Authors: Pant, Vinod, Mariano, Piero, Kanduri, Chandrasekhar, Mattsson, Anita, Lobanenkov, Victor, Heuchel, Rainer, Ohlsson, Rolf
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC196004/
https://ncbi.nlm.nih.gov/pubmed/12629040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.254903
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