p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human Chromosome 19q13.3

p190RhoGAP and Rho are key regulators of oligodendrocyte differentiation. The gene encoding p190RhoGAP is located at 19q13.3 of the human chromosome, a locus that is deleted in 50%–80% of oligodendrogliomas. Here we provide evidence that p190RhoGAP may suppress gliomagenesis by inducing a differenti...

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Detalhes bibliográficos
Main Authors: Wolf, Rebecca M., Draghi, Nicole, Liang, Xiquan, Dai, Chengkai, Uhrbom, Lene, Eklöf, Charlotta, Westermark, Bengt, Holland, Eric C., Resh, Marilyn D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC196001/
https://ncbi.nlm.nih.gov/pubmed/12600941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1040003
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