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Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor
Mutations in the NF1 tumor suppressor underlie the familial tumor predisposition syndrome neurofibromatosis type I. Although its encoded protein, neurofibromin, functions as a Ras–GTPase activating protein (GAP), nothing is known about how it is normally regulated or its precise role in controlling...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC195996/ https://ncbi.nlm.nih.gov/pubmed/12600938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1054703 |
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