Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor

Mutations in the NF1 tumor suppressor underlie the familial tumor predisposition syndrome neurofibromatosis type I. Although its encoded protein, neurofibromin, functions as a Ras–GTPase activating protein (GAP), nothing is known about how it is normally regulated or its precise role in controlling...

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Detalhes bibliográficos

Publicado no:	Genes Dev
Principais autores:	Cichowski, Karen, Santiago, Sabrina, Jardim, Melanie, Johnson, Bryan W., Jacks, Tyler
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cold Spring Harbor Laboratory Press 2003
Assuntos:	Research Communication
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC195996/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12600938/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1054703
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