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Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor

Mutations in the NF1 tumor suppressor underlie the familial tumor predisposition syndrome neurofibromatosis type I. Although its encoded protein, neurofibromin, functions as a Ras–GTPase activating protein (GAP), nothing is known about how it is normally regulated or its precise role in controlling...

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Udgivet i:Genes Dev
Principais autores: Cichowski, Karen, Santiago, Sabrina, Jardim, Melanie, Johnson, Bryan W., Jacks, Tyler
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2003
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC195996/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12600938/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1054703
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