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Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-α-phenylnitrone

According to the free radical theory of aging, reactive oxygen species cause oxidative damage, proposed to be an underlying factor of the aging process. In the current study, we have used electron paramagnetic resonance spin labeling, measurements of protein carbonyl content, an index of protein oxi...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Butterfield, D. Allan, Howard, Beverly J., Yatin, Servet, Allen, Kerry L., Carney, John M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19572/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9012843/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.2.674
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