Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

Oxygen free radicals and oxidative events have been implicated as playing a role in bringing about the changes in cellular function that occur during aging. Brain readily undergoes oxidative damage, so it is important to determine if aging-induced changes in brain may be associated with oxidative ev...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Carney, J M, Starke-Reed, P E, Oliver, C N, Landum, R W, Cheng, M S, Wu, J F, Floyd, R A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51506/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1673789/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.9.3633
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