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Development and function of T cells in T cell antigen receptor/CD3 ζ knockout mice reconstituted with FcɛRI γ

Engagement of α–β T cell receptors (TCRs) induces many events in the T cells bearing them. The proteins that transduce these signals to the inside of cells are the TCR-associated CD3 polypeptides and ζ–ζ or ζ–η dimers. Previous experiments using knockout (KO) mice that lacked ζ (ζKO) showed that ζ i...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Liu, Chih-Pin, Lin, Wei-Jen, Huang, Manley, Kappler, John W., Marrack, Philippa
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19562/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9012833/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.2.616
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