Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death

Stroke is among the three leading causes of death worldwide and the most frequent cause of permanent disability. Brain ischemia induces an inflammatory response involving activated complement fragments. Here we show that i.v. Ig (IVIG) treatment, which scavenges complement fragments, protects brain...

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Hlavní autoři: Arumugam, Thiruma V., Tang, Sung-Chun, Lathia, Justin D., Cheng, Aiwu, Mughal, Mohamed R., Chigurupati, Srinivasulu, Magnus, Tim, Chan, Sic L., Jo, Dong-Gyu, Ouyang, Xin, Fairlie, David P., Granger, Daniel N., Vortmeyer, Alexander, Basta, Milan, Mattson, Mark P.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1955802/
https://ncbi.nlm.nih.gov/pubmed/17715065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700506104
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