Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death

Stroke is among the three leading causes of death worldwide and the most frequent cause of permanent disability. Brain ischemia induces an inflammatory response involving activated complement fragments. Here we show that i.v. Ig (IVIG) treatment, which scavenges complement fragments, protects brain...

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Detalhes bibliográficos
Main Authors: Arumugam, Thiruma V., Tang, Sung-Chun, Lathia, Justin D., Cheng, Aiwu, Mughal, Mohamed R., Chigurupati, Srinivasulu, Magnus, Tim, Chan, Sic L., Jo, Dong-Gyu, Ouyang, Xin, Fairlie, David P., Granger, Daniel N., Vortmeyer, Alexander, Basta, Milan, Mattson, Mark P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1955802/
https://ncbi.nlm.nih.gov/pubmed/17715065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700506104
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