A mutation of the atrial natriuretic peptide (guanylyl cyclase-A) receptor results in a constitutively hyperactive enzyme

Mutation of an invariant glutamate residue found within the catalytic domain of guanylyl cyclases resulted in a dramatic 14-fold increase in the activity of the guanylyl cyclase-A receptor. Even in the presence of Mn(2+)/Triton X-100, a treatment previously thought to yield hormone-independent and m...

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Bibliographic Details
Main Authors: Wedel, Barbara J., Foster, David C., Miller, Deborah E., Garbers, David L.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences of the USA 1997
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC19534/
https://ncbi.nlm.nih.gov/pubmed/9012805
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