A mutation of the atrial natriuretic peptide (guanylyl cyclase-A) receptor results in a constitutively hyperactive enzyme

Mutation of an invariant glutamate residue found within the catalytic domain of guanylyl cyclases resulted in a dramatic 14-fold increase in the activity of the guanylyl cyclase-A receptor. Even in the presence of Mn(2+)/Triton X-100, a treatment previously thought to yield hormone-independent and m...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Wedel, Barbara J., Foster, David C., Miller, Deborah E., Garbers, David L.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1997
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19534/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9012805/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.2.459
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