A mutation of the atrial natriuretic peptide (guanylyl cyclase-A) receptor results in a constitutively hyperactive enzyme
Mutation of an invariant glutamate residue found within the catalytic domain of guanylyl cyclases resulted in a dramatic 14-fold increase in the activity of the guanylyl cyclase-A receptor. Even in the presence of Mn(2+)/Triton X-100, a treatment previously thought to yield hormone-independent and m...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1997
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19534/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9012805/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.2.459 |
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