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A mouse cell-adapted NS4B mutation attenuates West Nile virus RNA synthesis
An adaptive mutation (E249G) within West Nile virus (WNV) NS4B gene was consistently recovered from replicon RNAs in C3H/He mouse cells. The E249G is located at the C-terminal tail of NS4B predicted to be on the cytoplasmic side of the endoplasmic reticulum membrane. The E249G substitution reduced r...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1952232/ https://ncbi.nlm.nih.gov/pubmed/17178141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2006.11.012 |
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