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Identification of the PIP(2)-binding site on Kir6.2 by molecular modelling and functional analysis

ATP-sensitive potassium (K(ATP)) channels couple cell metabolism to electrical activity by regulating K(+) fluxes across the plasma membrane. Channel closure is facilitated by ATP, which binds to the pore-forming subunit (Kir6.2). Conversely, channel opening is potentiated by phosphoinositol bisphos...

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Bibliografski detalji
Glavni autori: Haider, Shozeb, Tarasov, Andrei I, Craig, Tim J, Sansom, Mark S P, Ashcroft, Frances M
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952224/
https://ncbi.nlm.nih.gov/pubmed/17673911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601809
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