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XIAP Activity Dictates Apaf-1 Dependency for Caspase 9 Activation

The current model for the intrinsic apoptotic pathway holds that mitochondrial activation of caspases in response to cytotoxic drugs requires both Apaf-1-induced dimerization of procaspase 9 and Smac/Diablo-mediated sequestration of inhibitors of apoptosis proteins (IAPs). Here, we showed that eithe...

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Autori principali: Ho, Andrew T., Li, Qin H., Okada, Hitoshi, Mak, Tak W., Zacksenhaus, Eldad
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952122/
https://ncbi.nlm.nih.gov/pubmed/17562856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00188-07
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