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XIAP Activity Dictates Apaf-1 Dependency for Caspase 9 Activation
The current model for the intrinsic apoptotic pathway holds that mitochondrial activation of caspases in response to cytotoxic drugs requires both Apaf-1-induced dimerization of procaspase 9 and Smac/Diablo-mediated sequestration of inhibitors of apoptosis proteins (IAPs). Here, we showed that eithe...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1952122/ https://ncbi.nlm.nih.gov/pubmed/17562856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00188-07 |
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