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Long-term enrichment enhances the cognitive behavior of the aging neurogranin null mice without affecting their hippocampal LTP
Neurogranin (Ng), a PKC substrate, is abundantly expressed in brain regions important for cognitive functions. Deletion of Ng caused severe deficits in spatial learning and LTP in the hippocampal CA1 region of mice. These Ng−/− mice also exhibit deficits in the amplification of their hippocampal sig...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Cold Spring Harbor Laboratory Press
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1951789/ https://ncbi.nlm.nih.gov/pubmed/17671107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/lm.636107 |
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