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Surface-Exposed Adeno-Associated Virus Vp1-NLS Capsid Fusion Protein Rescues Infectivity of Noninfectious Wild-Type Vp2/Vp3 and Vp3-Only Capsids but Not That of Fivefold Pore Mutant Virions

Over the past 2 decades, significant effort has been dedicated to the development of adeno-associated virus (AAV) as a vector for human gene therapy. However, understanding of the virus with respect to the functional domains of the capsid remains incomplete. In this study, the goal was to further ex...

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Detalhes bibliográficos
Main Authors: Grieger, Joshua C., Johnson, Jarrod S., Gurda-Whitaker, Brittney, Agbandje-McKenna, Mavis, Samulski, R. Jude
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951316/
https://ncbi.nlm.nih.gov/pubmed/17507473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00580-07
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