Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice

BACKGROUND: Tobacco smoke is the principal risk factor for chronic obstructive pulmonary disease (COPD), though the mechanisms of its toxicity are still unclear. The ABC transporters multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp/MDR1) extrude a wide variety of toxic subst...

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Detalhes bibliográficos
Main Authors: van der Deen, Margaretha, Timens, Wim, Timmer-Bosscha, Hetty, van der Strate, Barry W, Scheper, Rik J, Postma, Dirkje S, de Vries, Elisabeth G, Kerstjens, Huib A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950505/
https://ncbi.nlm.nih.gov/pubmed/17617921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-8-49
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