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GAD1 mRNA Expression and DNA Methylation in Prefrontal Cortex of Subjects with Schizophrenia

Dysfunction of prefrontal cortex in schizophrenia includes changes in GABAergic mRNAs, including decreased expression of GAD1, encoding the 67 kDa glutamate decarboxylase (GAD(67)) GABA synthesis enzyme. The underlying molecular mechanisms remain unclear. Alterations in DNA methylation as an epigene...

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Bibliografiske detaljer
Main Authors: Huang, Hsien-Sung, Akbarian, Schahram
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950080/
https://ncbi.nlm.nih.gov/pubmed/17726539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000809
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