Evidence that the beta-catenin nuclear translocation assay allows for measuring presenilin 1 dysfunction.

BACKGROUND: Mutations in the presenilin (PSEN) genes are responsible for the majority of early-onset Alzheimer disease (AD) cases. PSEN1 is a component of a high molecular weight, endoplasmic reticulum, membrane-bound protein complex, including beta-catenin. Pathogenic PSEN1 mutations were demonstra...

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Main Authors: Van Gassen, G., De Jonghe, C., Nishimura, M., Yu, G., Kuhn, S., St George-Hyslop, P., Van Broeckhoven, C.
Formato: Artigo
Idioma:Inglês
Publicado: 2000
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1949967/
https://ncbi.nlm.nih.gov/pubmed/10997338
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