Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease.

BACKGROUND: Mutations in the presenilin proteins cause early-onset, familial Alzheimer's disease (FAD). MATERIALS AND METHODS: We characterized the cellular localization and endoproteolysis of presenilin 2 (PS2) and presenilin 1 (PS1) in brains from 25 individuals with presenilin-mutations caus...

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Bibliografske podrobnosti
Main Authors: Mathews, P. M., Cataldo, A. M., Kao, B. H., Rudnicki, A. G., Qin, X., Yang, J. L., Jiang, Y., Picciano, M., Hulette, C., Lippa, C. F., Bird, T. D., Nochlin, D., Walter, J., Haass, C., Lévesque, L., Fraser, P. E., Andreadis, A., Nixon, R. A.
Format: Artigo
Jezik:Inglês
Izdano: 2000
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1949913/
https://ncbi.nlm.nih.gov/pubmed/11126202
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