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Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives. Insights from molecular modeling studies

Four enantiomerically pure (S)-4-alkylthioamphetamine derivatives were evaluated as monoamine oxidase (MAO) inhibitors using the human and rat isoforms of the enzyme. Molecular dockings were performed in order to gain insights regarding the binding mode of these inhibitors. All compounds were potent...

詳細記述

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書誌詳細
主要な著者: Fierro, Angélica, Osorio-Olivares, Mauricio, Cassels, Bruce K., Edmondson, Dale E., Sepúlveda-Boza, Silvia, Reyes-Parada, Miguel
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1949415/
https://ncbi.nlm.nih.gov/pubmed/17521909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.05.021
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