A lymphocytic choriomeningitis virus glycoprotein variant that is retained in the endoplasmic reticulum efficiently cross-primes CD8(+) T cell responses

Recent studies indicate that T cell cross-priming preferentially occurs against long-lived, stable proteins. We have studied cross-priming by using the glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV), a protein that normally is not MHC class I cross-presented. This study shows that a...

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Detalhes bibliográficos
Main Authors: Freigang, Stefan, Eschli, Bruno, Harris, Nicola, Geuking, Markus, Quirin, Katharina, Schrempf, Sabrina, Zellweger, Raphael, Weber, Jacqueline, Hengartner, Hans, Zinkernagel, Rolf M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948914/
https://ncbi.nlm.nih.gov/pubmed/17686978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704423104
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