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Tumor Necrosis Factor-α Causes Accumulation of a Ubiquitinated Form of Hypoxia Inducible Factor-1α through a Nuclear Factor-κB-Dependent Pathway

Hypoxia-inducible factor-1 (HIF-1) is a regulator of metabolic adaptation to hypoxia. It is now appreciated that HIF-1α accumulation is achieved under normoxic conditions by various factors, such as TNF-α. Here, it was our intention to gain insight into the signaling mechanisms used by TNF-α to stim...

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Bibliografski detalji
Glavni autori: Zhou, Jie, Schmid, Tobias, Brüne , Bernhard
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2003
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC194872/
https://ncbi.nlm.nih.gov/pubmed/12808024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E02-09-0598
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