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Detecting Ultraviolet Damage in Single DNA Molecules by Atomic Force Microscopy

We report detection and quantification of ultraviolet (UV) damage in DNA at a single molecule level by atomic force microscopy (AFM). By combining the supercoiled plasmid relaxation assay with AFM imaging, we find that high doses of medium wave ultraviolet (UVB) and short wave ultraviolet (UVC) ligh...

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Detalles Bibliográficos
Main Authors: Jiang, Yong, Ke, Changhong, Mieczkowski, Piotr A., Marszalek, Piotr E.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948057/
https://ncbi.nlm.nih.gov/pubmed/17483180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.108209
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