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Molecular Dynamics Simulations on the Oligomer-Formation Process of the GNNQQNY Peptide from Yeast Prion Protein Sup35

Oligomeric intermediates are possible cytotoxic species in diseases associated with amyloid deposits. Understanding the early steps of fibril formation at atomic details may provide useful information for the rational therapeutic design. In this study, using the heptapeptide GNNQQNY from the yeast p...

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Bibliografiske detaljer
Main Authors: Zhang, Zhuqing, Chen, Hao, Bai, Hongjun, Lai, Luhua
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948036/
https://ncbi.nlm.nih.gov/pubmed/17483185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.100537
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