Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex

BACKGROUND: The positive transcription elongation factor, P-TEFb, comprised of cyclin dependent kinase 9 (Cdk9) and cyclin T1, T2 or K regulates the productive elongation phase of RNA polymerase II (Pol II) dependent transcription of cellular and integrated viral genes. P-TEFb containing cyclin T1 i...

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Detalhes bibliográficos
Main Authors: Biglione, Sebastian, Byers, Sarah A, Price, Jason P, Nguyen, Van Trung, Bensaude, Olivier, Price, David H, Maury, Wendy
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948018/
https://ncbi.nlm.nih.gov/pubmed/17625008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-4-47
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