Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation
Affinity maturation of antibodies requires localized hypermutation and antigen selection. Hypermutation is particularly active in certain regions (notably the CDRs of light and heavy chains) due to the local accumulation of hot spots. We have now analyzed the role of individual nucleotides in the or...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1996
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19480/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8943046/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.24.13979 |
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