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Short telomeres limit tumor progressionin vivo by inducing senescence
Telomere maintenance is critical for cancer progression. To examine mechanisms of tumor suppression induced by short telomeres we crossed mice deficient for the RNA component of telomerase, mTR-/-, with Eμ-Myc transgenic mice; an established model of Burkitt’s lymphoma. Short telomeres suppressed tu...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1945093/ https://ncbi.nlm.nih.gov/pubmed/17433785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.02.026 |
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