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The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: Replication protein A hyperphosphorylation and p53 induction

Severe combined immunodeficient (SCID) mice display an increased sensitivity to ionizing radiation compared with the parental, C.B-17, strain due to a deficiency in DNA double-strand break repair. The catalytic subunit of DNA-dependent protein kinase (DNA-PK(CS)) has previously been identified as a...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Fried, Laura M., Koumenis, Constantinos, Peterson, Scott R., Green, Susannah L., van Zijl, Pierre, Allalunis-Turner, Joan, Chen, David J., Fishel, Richard, Giaccia, Amato J., Brown, J. Martin, Kirchgessner, Cordula U.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1996
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19439/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8943020/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.24.13825
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