The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: Replication protein A hyperphosphorylation and p53 induction

Severe combined immunodeficient (SCID) mice display an increased sensitivity to ionizing radiation compared with the parental, C.B-17, strain due to a deficiency in DNA double-strand break repair. The catalytic subunit of DNA-dependent protein kinase (DNA-PK(CS)) has previously been identified as a...

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Detalles Bibliográficos
Autores principales: Fried, Laura M., Koumenis, Constantinos, Peterson, Scott R., Green, Susannah L., van Zijl, Pierre, Allalunis-Turner, Joan, Chen, David J., Fishel, Richard, Giaccia, Amato J., Brown, J. Martin, Kirchgessner, Cordula U.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences of the USA 1996
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC19439/
https://ncbi.nlm.nih.gov/pubmed/8943020
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