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A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery

The U.S. National Cancer Institute has used a panel of 60 diverse human cancer cell lines (the NCI-60) to screen >100,000 chemical compounds for anticancer activity. However, not all important cancer types are included in the panel, nor are drug responses of the panel predictive of clinical effic...

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Main Authors: Lee, Jae K., Havaleshko, Dmytro M., Cho, HyungJun, Weinstein, John N., Kaldjian, Eric P., Karpovich, John, Grimshaw, Andrew, Theodorescu, Dan
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2007
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1941805/
https://ncbi.nlm.nih.gov/pubmed/17666531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610292104
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