Ectopic expression of N-acetylglucosaminyltransferase III in transgenic hepatocytes disrupts apolipoprotein B secretion and induces aberrant cellular morphology with lipid storage
N-Acetylglucosaminyltransferase III (GnT-III) produces “bisecting-GlcNAc” and regulates the branching of N-glycans. GnT-III activity is elevated during hepatocarcinogenesis, which is in contrast to the undetectable level found in normal hepatocytes. To determine the biological significance of GnT-II...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1998
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19400/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9482919/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.5.2526 |
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