Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines

Oxygenated sterols such as 25-hydroxycholesterol kill Chinese hamster ovary cells because they inhibit the proteolytic processing of sterol regulatory element binding proteins (SREBPs), a pair of membrane-bound transcription factors that activate genes controlling cholesterol synthesis and uptake fr...

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Bibliografiska uppgifter
Huvudupphovsmän: Nohturfft, Axel, Hua, Xianxin, Brown, Michael S., Goldstein, Joseph L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences of the USA 1996
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC19399/
https://ncbi.nlm.nih.gov/pubmed/8942999
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