Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines

Oxygenated sterols such as 25-hydroxycholesterol kill Chinese hamster ovary cells because they inhibit the proteolytic processing of sterol regulatory element binding proteins (SREBPs), a pair of membrane-bound transcription factors that activate genes controlling cholesterol synthesis and uptake fr...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Nohturfft, Axel, Hua, Xianxin, Brown, Michael S., Goldstein, Joseph L.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1996
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19399/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8942999/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.24.13709
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!