Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma

Glioblastoma multiforme (GBM) is the most aggressive brain tumor in adults and remains incurable despite multimodal intensive treatment regimens. EGFRvIII is a truncated extracellular mutant of the EGF receptor (EGFR) commonly found in GBMs that confers enhanced tumorigenic behavior. To gain a molec...

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Bibliographic Details
Main Authors: Huang, Paul H., Mukasa, Akitake, Bonavia, Rudy, Flynn, Ryan A., Brewer, Zachary E., Cavenee, Webster K., Furnari, Frank B., White, Forest M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1937558/
https://ncbi.nlm.nih.gov/pubmed/17646646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705158104
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