Phage escape libraries for checkmate analysis

Ligand-binding epitopes of proteins can mutate rapidly, as shown by viral mutations that lead to escape from neutralizing antibodies. We have undertaken to recreate in vitro the evolutionary competition between viral mutations that allow escape from antibody binding and host mutations that generate...

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Bibliografiske detaljer
Main Authors: Dickerson, Tobin J., McKenzie, Kathleen M., Hoyt, Amanda S., Wood, Malcolm R., Janda, Kim D., Brenner, Sydney B., Lerner, Richard A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1937530/
https://ncbi.nlm.nih.gov/pubmed/17646645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705362104
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